Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression
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چکیده
منابع مشابه
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.
Multidrug resistance protein 4 (MRP4; ABCC4) is an ATP binding cassette transporter that facilitates the excretion of bile salt conjugates and other conjugated steroids in hepatocytes and renal proximal tubule epithelium. MRP4/Mrp4 undergoes adaptive upregulation in response to oxidative and cholestatic liver injury in human and animal models of cholestasis. However, the molecular mechanism of ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology
سال: 2010
ISSN: 0193-1857,1522-1547
DOI: 10.1152/ajpgi.00522.2010